Anaesthetic



Patented Sept. 26. 1933 1 1,928,346

ANZESTHETIC Meyer L. Axelrod, Cleveland, Ohio, assignor of gfltiy per cent to Harry Fraiberg, Cleveland,

No Drawing. Application December 5, 1930 Serial No. 500,427

12 Claims. (Cl. 167-52) My invention relates to improvements in hyp- Phanodorn cyclohexenyl ethyl barbiturio notic compounds, particularly analgesics and acid. anaesthetics. In the administration of anaes- Amytal-isoamyl ethyl barbituric acid.

thetics or analgesics, particularly for obstetrical Ipral (acid form)-ethyl isopropyl barbituric operations, the usual practice has been to await acid.

until a certain amount of dilation of the cervix Pernokton-secondary butyl bromallyl barbihas taken place before administering the particuturic acid. lar anaesthetic. It is common knowledge that the Phenobarbital-phenyl ethyl barbituric acid labor pains prior to the aforesaid dilation are (Luminal).

0 excruciating but may be relieved by the use of Barbital-diethyl barbituric acid (Veronal). 65

morphine or similar narcotics. However, such In actual use, the patient is first given enemas administrations are apt to have an undesired until the return is clear, after which the barbieilect upon the patient and the child and does not turic preparation is instilled. The instillation of always serve the intended purpose. the barbituric compound may be preceded by an It is therefore one of the objects of my invenounce of plain oil, also Vaseline is applied to the 70 tion to provide a hypnotic compound which may anus to prevent possible irritation should the be administered to the patient in the first stage compound be expelled. A slow uniform rate of of labor to permit uterine contractions and relieve instillation is established and the mixture perthe initial pains as well as the pains in the other mitted to enter the colon between uterine constages of labor. traCtiOnS- 5 Still another object of my invention is to pro- The compound may include a mixture of vide an anasthetic which may be easily and safemineral oil, ether, quinine and a barbiturate. The ly administered to the patient and which tends to oil used may be either a mineral oil or vegetable eliminate the nervous condition which sometimes 011 uc a Olive HOWEVBI', mineral Oil is p accompany the administration of anaesthetics. fcrred as it does not tend to turn rancid. It is I am aware that ether and oil with quinine have may be more quickly put into solution by using a Another object of my invention is to provide an also to be understood that the proportions of anaesthetic which may be administered during the the ingredients in the compound may be varied first stages of labor and which is sufliciently lastto procure difierent degrees of anaesthesia. ing in its efiects to maintain the patient under I have observed in my various experiences at its analgesic influence throughout the entire dethe solution can be made either with or without 1ivery the aid of solvents other than the ether. In

Still other objects and uses of my new comsome ether the alcohol content is relatively high pound will become apparent from the following and therefore the quinine is more expeditiously description thereof. put into solution. I also find that the quinine been heretofore administered to the patient by small amount of other solvents, such as ethyl rectal instillation for obtaining analgesia; howalcohol, and when so used, I find that approxiever, as previously stated, this administration mately three fluid drains of ethyl alcohol in a cannot be applied with success to the patient unfour fluid ounce solution of the compound is sufiitil after the first stages of labor have passed becient for all purposes of solubility. cause of the short duration of its eflect. I am I have found that a mixture of 1 ounces also aware that barbiturates have been used with mineral oil, 2 ounces ether, 20 grains quinine inhalation anaesthetics. I believe the use of the alkaloid, together with a mixture of two barbitubarbiturates in the manner which I am about to rates which are known to the profession as disclose, is distinctly new. There are at the presnembutal (acid form) and neonal, which barbi- 190 ent time, a number of commercial barbiturates, u a s a et y (l-mcthyl y barbitulic some of which better suit themselves than others, acid, and n-butyl ethyl barbituric acid respecto my particular compound. Among the more tively, in the proportion of 8 grains nembutal useful barbiturates I have used are the following: (acid form) and 5 grains neonal produce a very 0 Nembutal (acid form)-ethyl (l-methyl butyl) satisfactory result. I find that a combination barbituric acid. of two or more barbiturates as described is some- Neonaln-butyl ethyl barbituric acid. times desirable. The effect is not additive but Allonala1lyl isopropyl barbituric acid plus due to the synergetic action between the two bar- 5 amidopyrine. biturates, each barbiturate enhances the action o Dial-diallyl barbituric acid. of the other, causing a substantially different eifect than is found from the use of either one alone. In the foregoing example ethyl (lmethylbutyl) barbituric acid is representative of a quick acting barbiturate which takes effect very shortly after administration, whereas the other is representative of a relatively slow acting barbiturate which in this instance may involve twice as much time before it becomes effective. This mixture may be administered as previously described and is particularly adaptable for analgesia during childbirth. Upon instillation of the above dosage, the average patient is susceptible to from 10 to 18 hours of complete amnesia and analgesia.

A compound made in accordance with my invention, from which the quinine is omitted may also be used for surgery. A particular combination for such use may be 2% ounces ether, 1%; ounces mineral oil and 10 grains of nembutal. It is very apparent-that the increased proportions of the barbiturate will give more complete anaesthesia. The dosage may be regulated according to body Weight, a patient weighing 130 pounds or over receiving the full 4 ounce mixture; those between 100 and 130 pounds receiving approximately of the contents and those under 100 pounds receiving /2 of the contents.

In actual use it has been found that the patient usually becomes drowsy within 30 minutes and gradually goes into a deep slumber. In time, (1 hour) most patients can be aroused but with great difliculty and the uterine contractions appear to be accelerated rather than interfered with. The dosage of the barbiturates may in some cases be regulated in such a manner that a supplemental anaesthesia may be required. The use of a compound as described, eliminates the use of drugs which may seriously afiect the baby or patient. It will also reduce the post operative need of narcotics. The pulse, respiration and blood pressure are not materially affected. The blood loss is not affected. Uterine contractions are not interfered with and the patient has no recollection of labor pains. No undesirable after effects have been observed.

Having thus described my compound and its method of use, I am aware that the exact proportions of the various ingredients may be varied, and should be varied to suit different cases, but

that such variation is well within the precepts of the invention and such as may be understood to those experienced in such matters and does not depart from the spirit of myinvention nor the scope of the appended claims.

I claim:

1. A hypnotic compound for rectal instillation comprising a solution of oil, ether and a barbiturate.

2. A hypnotic compound for rectal instillation comprising a mixture of oil and ether and an oil and ether soluble barbiturate.

3. A hypnotic compound for rectal instillation comprising a mixture of mineral oil and ether and an oil and ether soluble barbiturate.

4. A hypnotic compound for rectal instillation comprising a mixture of mineral oil and ether and a barbiturate.

5. A hypnotic compound for rectal instillation comprising a mixture of oil, ether and two or more of the barbiturates.

6 A hypnotic compound for rectal instillation comprising a mixture of oil, ether and oil and ether soluble barbiturates.

7. A hypnotic compound for rectal instillation comprising a mixture of oil, ether, and ethyl (1-methyl butyl) barbituric acid-and n-butylethyl-barbituric-acid.

8. A hypnotic compound for rectal instillation comprising a mixture of mineral oil, ether and ethyl (l-methyl butyl) barbituric-acid.

9. A-hypnotic compound for rectal instillation comprising a mixture of mineral oil, ether and n-butylethylbarbituric-acid.

10. A hypnotic compound for rectal instillation comprising a mixture of mineral oil, ether and ethyl (l-methyl butyl) barbituric-acid and n-butyl-ethyl-barbituric-acid.

11. An analgesic comprising a mixture in the proportions-mineral oil 1 /2 ounces, ether 2%; ounces, and ethyl (l-methyl butyl) barbituricacid 8 grains and n-butyl-ethyl-barbituric-acid 

